Glycan-deficient PrP stimulates VEGFR2 signaling via glycosaminoglycan
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چکیده
منابع مشابه
Glycosaminoglycan modification of neuropilin-1 modulates VEGFR2 signaling.
Neuropilin-1 (NRP1) is a co-receptor for vascular endothelial growth factor (VEGF) that enhances the angiogenic signals cooperatively with VEGFR2. VEGF signaling is essential for physiological and pathological angiogenesis through its effects on vascular endothelial cells (ECs) and smooth muscle cells (SMCs), but the mechanisms coordinating this response are not well understood. Here we show th...
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Vascular endothelial growth factor (VEGF)-A and the VEGF receptors are critical for regulating angiogenesis during development and homeostasis and in pathological conditions, such as cancer and proliferative retinopathies. Most effects of VEGF-A are mediated by the VEGFR2 and its coreceptor, neuropilin (NRP)-1. Here, we show that VEGFR2 is shed from cells by the metalloprotease disintegrin ADAM...
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ژورنال
عنوان ژورنال: Cellular Signalling
سال: 2016
ISSN: 0898-6568
DOI: 10.1016/j.cellsig.2016.03.010